Steven Klein

Overgrowth disorders are a group of genetic diseases that manifest as abnormal growth of the body, or body parts, that are commonly first noted at birth such that standard growth measurements are recorded to be 2–3 standard deviations (SD) above the mean for sex and age. Some of these syndromes, such as Perlman, Sotos, and Beckwith-Widemann,  are associated with an increased risk of specific solid tumors, including Wilms, hepatoblastomas and neuroblastomas. Other conditions present with asymmetric somatic overgrowth, as is the case for CLOVES and Proteus syndromes. The predisposition to tumorigenesis suggests that the genetic changes associated with these rare disorders could also be present in sporadic forms of cancer and allows us to better understand the genetics of cancer and organ growth.

 

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